Genes and parkinsonism.
نویسندگان
چکیده
منابع مشابه
New Genes Causing Hereditary Parkinson’s Disease or Parkinsonism
PURPOSE OF REVIEW This article reviews was to review genes where putative or confirmed pathogenic mutations causing Parkinson's disease or Parkinsonism have been identified since 2012, and summarizes the clinical and pathological picture of the associated disease subtypes. RECENT FINDINGS Newly reported genes for dominant Parkinson's disease are DNAJC13, CHCHD2, and TMEM230. However, the evid...
متن کاملParkinsonism and Related Disorders
a-Synuclein (a-syn) aggregation is central to neuropathological changes in Parkinson’s disease. The aggregates spread within the central nervous system according to a very predictable pattern. A prion-like transmission of a-syn aggregates has been recently proposed to explain this propagation pattern. First, we review the growing evidence for such a mechanism. This process is likely to occur in...
متن کاملParkinsonism and Related Disorders
Excessive daytime sleepiness (EDS) is common in Parkinson’s Disease (PD). Actigraphy uses periods of immobility as surrogate markers of nighttime sleep but there are no examples of its use in assessing EDS of PD. A commercial wrist worn system for measuring bradykinesia and dyskinesia also detects 2 min periods of immobility, which have a 85.2% concordance with the detection of sleep by ambulat...
متن کاملParkinsonism and Related Disorders
Background and purpose: Quantitative analysis of brain atrophy may be useful in differentiating Parkinson’s Disease (PD) from Progressive Supranuclear Palsy (PSP) and parkinsonian variant of Multiple System Atrophy (MSA-P); the aim of this study was to identify the volumetric differences of subcortical structures in patients with PD, PSP and MSA-P using a novel and validated fully-automated who...
متن کاملParkinsonism and Related Disorders
People with Parkinson’s disease (PD) have difficulty performing dual tasks or simultaneous movements, even if the same movements can be easily performed individually. This has particular significance clinically, as for example falling injuries may occur if care is not taken to perform tasks one at a time. We investigated whether this difficultyx results from impaired dopamine-modulated connecti...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1997
ISSN: 0022-3050
DOI: 10.1136/jnnp.62.4.305